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KMID : 1101320050370020129
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Korean Journal of Clinical Laboratory Science
2005 Volume.37 No. 2 p.129 ~ p.137
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Anti-Obesitic Effect of Mulberry Root-Bark (Mori radicis Cortex) in Zucker Rats with High Lipid Diet Induced-Obesity
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Hong Seong-Hee
Kim Dong-Kyu
Lee Nam-Jin
Cho Jung-Hee
Kang Jong-Koo
Kim Yun-Bae
Park Jung-Hui
Hwang Seock-Yeon
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Abstract
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This study was performed to investigate the anti-obesitic effect of mulberry root-bark on male and female Zucker FA/FA or FA/fa rats. Obesity in the rats was induced by feeding high-lipid diet contained 3% corn oil and 1% cholesterol. Experimental groups in male and female rats were assigned to normal diet group (normal control), high-lipid diet group(positive control) and 3% mulberry root-bark powder in high-lipid diet group (MRC). The mulberry treated-group showed decreases of body weight, FER (food efficiency ratio) value and lipid peroxidation in the liver and increase of high density lipoprotein cholesterol (HDL-C) value, compared with positive control groups. Our findings suggest that mulberry root-bark has a potential role in preventing or improving obesity from the following points of view, body weight, serum lipids and antioxidant enzyme activities.
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KEYWORD
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Zucker rats, Mulberry root, Anti-obesity
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